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doi: 10.1038/s41591-022-02026-4

Indications: resulting either from organic heart disease or from cardiac surgical procedures inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility Contraindications: Patients with idiopathic hypertrophic subaortic stenosis (IHSS) and in patients who have shown previous manifestations of hypersensitivity to dobutamine Patients with IHSS have an asymmetric septal hypertrophy resulting in a dynamic left ventricular outflow obstruction (LVOT)

those of overdose and hospitalization-required intoxicationare very extreme instances of substance abuse