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doi: 10.1158/1535-7163.Mct-21-0071 24 ThompsonRMDytfeldDReyesLRobinsonRMSmithBManevichYet al

Similar to autoimmune disorders, mast cells become overzealous in doing their job, releasing histamines and cytokines, like a security alarm constantly going off when theres no real danger

Grey Literature Search dates : March 25-April 1, 2022 Keywords : Wegovy (semaglutide), weight management Limits : Publication years: none Updated : Search updated before the completion of stakeholder feedback period Relevant websites from the following sections of the CADTH grey literature checklist Grey Matters: A Practical Tool for Searching Health-Related Grey Literature were searched: Health Technology Assessment Agencies Health Economics Clinical Practice Guidelines Drug and Device Regulatory Approvals Advisories and Warnings Drug Class Reviews Clinical Trials Registries Databases (free) Internet Search Open Access Journals Appendix 2

It belongs to a novel class of agents known as triple agonists, targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors simultaneously