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When the primary injury occurs, the cerebrovascular system vibrates and be torn due to the external force, leading to shedding of vascular endothelial cells and loosening of tight junctions between endothelial cells, resulting in increased BBB permeability, release of activated leukocytes, inflammatory factors, glial cells, and substances toxic to neurons into the brain parenchyma, causing inflammation and immune reactions [20]
Now we understand that obesity is a complex, chronic disease driven by powerful biological factors
Environmental in this case means anything that started outside of our own bodies and got in
That distinction is not just semantics
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