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They may also have subclinical conditions that could be affected by metabolic changes

In one small study involving 8 healthy women, intravenous DSIP did not significantly affect growth hormone or prolactin secretion, and no human trials have demonstrated anabolic or physique-enhancing effects

In agreement with the involvement of IMPDH2 in favoring cancer progression 52,53,54 , IMPDH2 degrader 354 provoked a reduction in HeLa cell viability, which was significantly higher in WT than in IMPDH2-overexpressing cells (HeLa 522-4), proving the involvement of the target in 354 cytotoxicity (Fig