The 2026 Part D out-of-pocket cap of $2,000 provides a ceiling but reaching it requires significant spending first
The following mnemonic can classify the severity of eye disease: "NO SPECS": [28] Class 0: No signs or symptoms Class 1: Only signs (limited to upper lid retraction and stare, with or without lid lag) Class 2: Soft tissue involvement (oedema of conjunctivae and lids, conjunctival injection, etc.) Class 3: Proptosis Class 4: Extraocular muscle involvement (usually with diplopia) Class 5: Corneal involvement (primarily due to lagophthalmos) Class 6: Sight loss (due to optic nerve involvement) Typically, the natural history of TAO follows Rundle's curve, which describes a rapid worsening during an initial phase, peaking at maximum severity, and then improvement to a static plateau without, however, resolving back to a normal condition
In the large cardiovascular outcomes trial reported in the Wegovy label, systolic blood pressure fell by a mean of 3.8 mmHg with semaglutide versus 0.5 mmHg with placebo at week 104, a difference of 3.3 mmHg from a baseline of 131 mmHg
The once-weekly injection model also provides stronger behavioral cues for adherencemany people find it easier to remember one specific day per week than daily intake requirements
