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This is a form of dosage adjustment

The dosing framework comes from extrapolation: murine studies scaled by body surface area, in vitro keratinocyte studies reverse-engineered to estimate required serum concentration, and anecdotal protocols from research communities using off-label peptides

Glutamate is the main excitatory amino acid in the mammalian brain 6 , where glutamate receptors, such as N-methyl-d-aspartate (NMDA) receptors, are widely distributed, particularly in the hypothalamus, hippocampus, and amygdala, as they play fundamental roles in neuronal signaling, affecting several key brain activities, such as synaptic stabilization, cognition, memory, learning, and cellular metabolism 7

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