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Madsen had first become interested in this rare form of pancreatic cancer when he was a postdoctoral researcher in Steiner's laboratory at the University of Chicago between 1981 and 1983

However, with sophisticated medications like glucagon-like peptide-1 (GLP-1) receptor agonists, the cold acts as a destructive force rather than a preservative

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Investigational long-acting GLP-1 formulations have noted injection-site issues: for instance, an early version of a high-dose once-monthly exenatide caused injection-site panniculitis (fat inflammation) in some patients