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The investigation was also supported by grants UL1RR025764 (University of Utah, Center for Clinical and Translational Sciences), UL1RR025005 (Johns Hopkins University, General Clinical Research Center), UL1RR025011 (University of Wisconsin, Clinical and Translational Research Core) M01-RR00034 (Ohio State University, General Clinical Research Center) and the Clinical Research Center, Children's Hospital of Michigan, given by the National Center for Research Resources, National Institutes of Health