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Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc
The difference reflects lower bioavailability of the oral form due to digestive breakdown
The medication does not cause physical dependence, and discontinuation does not trigger acute medical emergencies
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