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Risk of Amputation: There is an increased risk of lower limb amputation (toes, feet) associated with empagliflozin, particularly in patients with prior amputations, peripheral vascular disease, neuropathy, and diabetic foot ulcers

The pipeline of next-generation treatments is advancing rapidly: Novo Nordisks CagriSema, a fixed-dose combination of semaglutide and the amylin analogue cagrilintide, has an FDA decision expected in late 2026 and could further accelerate the market

This has real clinical implications: Higher PIH Risk Any skin inflammation acne, a rash, even a scratch is more likely to leave behind a dark mark in Indian skin compared to lighter skin tones