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While the trial was not designed to formally disentangle weight lossmediated vs weightindependent mechanisms, the magnitude and durability of weight loss likely play a substantial role in risk modification. Clinicians should note that in SELECT, treatment discontinuation due to adverse events was 16% on semaglutide vs 8% on placebo, largely driven by GI events

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Nausea typically peaks within 24 to 72 hours and gradually subsides by the end of the first week