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When medications are either not effective or poorly tolerated, RAI is employed, which commonly renders the patient hypothyroid, thus requiring lifelong supplementation of thyroid hormones

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While human smoking studies remain limited, this biological mechanism provides a plausible explanation for why some patients report easier smoking cessation while on GLP-1 therapy

For instance, normal (healthy) RBCs have a steady SI parameter of 0.68, while hardened RBCs with 0.01% and 0.02% GA exhibit a steady SI parameter of 0.64 and 0.5, respectively (Fig