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A number of patients do regain weight once they cease, which is a characteristic common to many weight loss medications

Koo et al., 2023)

In clinical trials, patients taking oral semaglutide lost an average of 17% of their body weight over 71 weeks, with 1 in 4 participants losing 20% or more

If cellulite remains visible after weight loss on semaglutide, topical treatments (caffeine creams, retinoids), dry brushing, massage, or professional procedures like radiofrequency or laser therapies may provide additional benefit