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Diclofenac Sodium Slower absorption (effect in 12 hours) Longer duration of action Ideal for chronic conditions like Rheumatoid Arthritis, Osteoarthritis & Ankylosing Spondylitis Often available as enteric-coated / sustained-release formulations Diclofenac Potassium Faster absorption (effect in 3060 minutes) Shorter duration Preferred for acute pain like migraine, dental pain, dysmenorrhea & post-operative pain Usually film-coated for rapid relief Key takeaway: Sodium = slow & sustained relief Potassium = fast & quick relief Rational selection of dosage form improves patient outcomes, safety, and effectiveness

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doi:10.1016/0006-291x(73)91459-9 Pickart L, Vasquez-Soltero JM, Margolina A

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