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SKU: 30776407478

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Activation of viscerosensory afferents to the NTS with systemic CCK To test whether leptin alters the activity of PPG neurons and their downstream targets in response to a visceral stimulus, a previously validated Fos assay was adapted (Maniscalco and Rinaman, 2013)

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2.2.1 TGF- TGF- is the most potent pro-fibrotic mediator, inducing ECM, EMT, and pro-fibrotic mediators production by promoting the binding of Smad2/3 to Smad4, and driving myofibroblast differentiation to promote the PF process (Hu et al., 2018