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The resulting decrease in antioxidant capacity further exacerbates oxidative stress and neuronal vulnerability in HD [166]

[DOI] [PubMed] [Google Scholar] 28.Newsome P.N., Ambery P

284 A similar phenomenon has been observed in Gln-dependent clear cell renal carcinoma (RCC), which competitively depletes environmental Gln, causing local Gln depletion and IL-23 release from tumor-infiltrating macrophages, which further activates Treg function to suppress tumor immunity