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In contrast, when discussing tirzepatide vs retatrutide, it is notable that retatrutide is a novel triple agonist that activates GLP-1, GIP, and glucagon receptors

A body composition substudy of the Phase 2 diabetes trial, published in The Lancet Diabetes & Endocrinology in 2025, used DXA scans to measure changes in fat and lean mass in 189 participants

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Long-acting glucagon-like peptide-1 receptor agonists have direct access to and effects on pro-opiomelanocortin/cocaine- and amphetamine-stimulated transcript neurons in the mouse hypothalamus