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But the concentration is now 20 mg/mL

The pharmacokinetics of LY3437943 (retatrutide) support once-weekly administration due to an elimination half-life of approximately 6 days. Jastreboff AM et al., Nature Medicine, 2023 This extended half-life is made possible by attaching a fatty acid chain to the peptide, allowing it to bind to albumin a common protein in your blood that acts like a slow-release carrier

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[11] Studies have shown that high-dosed pectin can reduce both diarrhea and constipation, [12,13] acting as a prebiotic and stimulating gut bifidobacteria in patients with IBS, effectively alleviating symptoms