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Clinical trials demonstrate that gradual dose escalation produces similar cumulative weight reduction compared to faster schedules, but with significantly fewer dropouts due to side effects

Study strengths and limitations Strengths of the study were that it included follow-up after 28 weeks off treatment, and the high rates of treatment adherence and trial completion

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Our case presents a rare and novel poisoning report as she was the first case of copper sulfate poisoning in Emam Reza hospital of Mashhad, in which the digestive system discomforts and disorders were the only signs and symptoms presented, contrary to our expectations