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Who Should Consider GLP-1 Drugs And Who Shouldn't Good Candidates BMI 30+ (obese) The primary indication for all weight-management GLP-1s BMI 27+ with a weight-related condition (diabetes, high blood pressure, sleep apnea, PCOS, fatty liver) Failed sustained weight loss through diet and exercise alone for 6+ months Pre-diabetic GLP-1s can prevent progression to Type 2 diabetes Cardiovascular risk Semaglutide specifically has proven heart protection Not Appropriate For Cosmetic weight loss of a few kilograms These are serious medications, not diet pills History of medullary thyroid cancer or MEN2 syndrome Absolute contraindication History of pancreatitis Relative contraindication

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Recommendations for weight management in osteoarthritis: a systematic review of clinical practice guidelines