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While the baseline FS% of the dogs in the EPIC trial were calculated before administration of pimobendan began, no minimum or maximum FS% was a criterion in selecting or excluding the dogs for the trial, and there is no indication from the final report that any subsequent FS% measurements were taken

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In cases of low glutathione levels, the limited negative feedback ensures sufficient formation of -glutamyl-cysteine from which glutathione is formed [810]

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