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10 The purpose of this review is to summarize the evidence regarding the clinical and cost-effectiveness of SEM 2.0 mg subcutaneous once-weekly injection compared to lower 0.5 mg and 1.0 mg doses or placebo for managing T2DM in adults

Safety flag: Severe or persistent GI symptoms, vomiting, diarrhea, dizziness, inability to keep fluids down, or severe abdominal pain should be discussed with your prescribing clinician promptly

In contrast, in North America, these rates were 5.4 and 3.1 per 100,000 for males and females, respectively [147]

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