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Additionally, instead of internalization, the conjugated drug may release payloads by linker cleavage within the tumor cell microenvironment (Figure 13B), killing not only target cells but also non-targeted cells nearby

Incidentally, the healthy reference range is 191-663 pg/ml and correlates closely with oral cobalamin intake, which is why the vitamin B12 blood level alone is not an adequate parameter to diagnose a deficiency (Herrmann and Obeid, 2014)

This strategy minimizes both waste and cost