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To confirm this hypothesis, in a rat model with diabetes (but without obesity), surgical diversion of the proximal intestine caused a rapid improvement in glycemia without a reduction in food intake or weight change [93]

Data have shown that among 25,212 tirzepatide-related ADE reports, common ADEs included nausea and vomiting while previously unreported ADEs included eructation, gastroesophageal reflux disease, hemorrhage at the site of drug injection, and hyperglycemia