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Yet, the startling reality is that metabolic and nutritional factors, many of which are modifiable, are now recognized as primary drivers of its pathogenesis, contributing to a global burden that afflicts over 300 million people (1)

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Despite high upfront costs, economic modeling suggests potential long-term value

Nature 509:105109 Mappangara I, Yusuf I, Aspar MA, Qanitha A (2022) Cyp2a6 gene polymorphism and severity of coronary atherosclerosis in indonesian male smokers: a pilot study