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In CLL, a higher OCR is associated with prognostically unfavorable factors such as advanced stage, unmutated IGHV status, ZAP-70 positivity, and high level of 2-microglobulin as well as development of drug resistance (17) and an increased risk of Richters transformation (38)

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While the outcomes of these trials, for either condition, will not be binding on other claims, they will be closely watched to see what kinds of payouts juries award to plaintiffs, which are likely to have a significant impact on negotiations