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CBF reductions Individuals and animals with AD exhibit reductions in CBF and impaired cerebrovascular reactivity, particularly in the hippocampus, thalamus, frontal, and occipital cortices, as assessed by arterial spin labeling magnetic resonance imaging [157, 177, 178]

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Hydrogen peroxide participates in autocatalytic covalent heme binding to the apoprotein of TPO molecule, thereby stabilizing the activity of the enzyme [141]