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Donation of these methyl groups is part of a small cycle: Resynthesis of methionine is depicted in Devlin, Figure 19.44 The step in which methionine is re-generated requires two important vitamin derivatives: Methyl-cobalamin, a derivative of vitamin B 12 , which donates the methyl group to homocysteine N -methyl-tetrahydrofolate, which donates its methyl group to cobalamin, and allows the reaction to continue