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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Rasic D., Zenko Sever A., Rasic F., Strbe S., Rasic Z., Djuzel A., Duplancic B., Boban Blagaic A., Skrtic A., Seiwerth S., et al
Controlled studies using validated appetite scales showed decreased hunger, increased satiety and reduced prospective food consumption scores with GLP-1 treatment, which translated into lower energy intake and weight reduction
For example, cagrilintide can reduce the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP), two potent orexigenic peptides, and increase the expression of proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART), two anorexigenic peptides, in the arcuate nucleus of the hypothalamus (Roth et al., 2018, Physiol Behav)
While previous studies have demonstrated that DDAVP can mitigate the risk of overcorrection 21 , some instances have shown it leading to inadequate sodium level increases or even decreases 16,19,20 , especially with unrestricted fluid intake 11
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