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Research has shown that GPER enhances lipolysis by upregulating adipose triglyceride lipase (ATGL) expression in adipocytes, promoting triglyceride hydrolysis and fatty acid -oxidation [31]

thus, selenium deficiency may be linked to a reduced antioxidant capacity in the brain

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According to the researchers, this adverse effect is due to inhibition of the A2A adenosine receptor, resulting in increased oxidative stress and production of inflammatory stimuli