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While mild gastrointestinal discomfort can occur as a side effect, it's crucial for those with a history of gastrointestinal issues to inform their doctors before starting these medications

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70 The European Medicines Agencys Pharmacovigilance Risk Assessment committee recommended risk minimization measures (RMM) for flupirtine (use only after other analgesics were trialled, patients restricted to up to two week-long treatments, with weekly LFT) due to concern of rare serious liver injury associated with long-term use of flupirtine