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14 Why the Difference MattersThe activation of two distinct hormonal pathways (GIP and GLP-1) by tirzepatide, compared to the single pathway (GLP-1) activated by semaglutide, is believed to be the underlying reason for the generally greater effects on weight loss and blood sugar control observed with tirzepatide in clinical studies.32 This dual mechanism provides a plausible scientific basis for why one drug might demonstrate more pronounced results than the other

As a result, GLP-1 drugs need to be taken long term to sustain their effectiveness and prevent rebound weight gain

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