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The biggest limitation is that the study cannot prove cause and effect, Sudhakaran says

Moreover, in monocrotaline induced PH mice, immune cell-driven perivascular inflammatory infiltration often precedes structural pulmonary vascular remodeling [86], highlighting the pivotal role of immune-inflammatory mechanisms in PH

Together with pharmacological studies, the results reveal the conserved binding mode of peptidic agonists and provide molecular details of agonist recognition underlying receptor subtype selectivity