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Mendhe S, Badge A, Ugemuge S, Chandi D

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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes GT and AC substitutions

Therefore, further investigation to identify which epigenetic factors, TFs or inflammatory mediators are directly responsible for establishing and maintaining these specific epigenetic memories in vivo would provide deeper mechanistic insights and shed light on potential therapeutic targets to prevent rUTIs and/or reverse the epigenetic imprinting that leads to increased susceptibility to recurrent disease