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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Grunvald E., Shah R., Hernaez R., Chandar A.K., Pickett-Blakely O., Teigen L.M., Harindhanavudhi T., Sultan S., Singh S., Davitkov P., et al

Preclinical data presented at ADA 2024 showed that HM15275 delivered superior weight loss efficacy compared to semaglutide (Wegovy) and tirzepatide (Zepbound), with relatively less reductions in lean mass

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A key enzyme in the anabolic utilization of ketone bodies is cytosolic acetoacetyl-CoA synthetase, which catalyses the coupling of acetoacetate to CoA in a reaction dependent on ATP with acetoacetyl-CoA as the product