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After the run, a negative control correction was applied and the mAb1 data and CCL18 data were normalized to the hCCL1 signal (corresponding to 100%) and plotted as a function of mAb1 concentrations using GraphPad Prism (GraphPad Software, La Jolla, CA)

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Key Takeaways Tirzepatide slows gastric emptying by 4050%, reducing oral glutathione bioavailability from 2030% to 1218% during the 2448 hour peak effect window

Active Gastrointestinal Fluid Losses For a subset of patients, especially during initiation or dose-escalation phases, gastrointestinal side effects can be pronounced: Nausea: Constant, low-grade nausea frequently creates a psychological aversion to swallowing anything, including plain water