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3.2 Lactoferrin activates IRS-1/PI3K/AKT to improve insulin resistance Studies have shown that LF upregulates insulin receptor (IR), insulin receptor substrate-1 (IRS-1), glucose transporter 4 (GLUT4), PI3K and AKT in liver protein expression (30), increases peroxisome proliferator-activated receptor and regulatory protein SIRT-1 expression (28), and is negatively correlated with chronic inflammation-induced metabolic disorders of insulin resistance, hyperglycemia, and obesity, and positively correlated with insulin sensitivity (48)

The expansion was made possible by our collaboration with Lilly and Novo Nordisk, said Harold Carter, Pharm.D., senior vice president of trade relations at Express Scripts

doi: 10.1042/bsr20201273 251 WangWGuoPChenMChenDChengYHeL

p = 0.001) (Supplementary Table 2)