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859 High serum ferritin levels are significantly associated with the prevalence of hand osteoarthritis, suggesting that inflammation and ferroptosis in fibrocartilage chondrocytes may be key pathways of osteoarthritis

doi:10.1001/archinte.166.18.1975

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Central to this inflammatory response is the activation of mast cells and microglia , two immune cell types that serve as primary responders to environmental stressors