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Most individuals with significant hypercholesterolemia do not have classic monogenic autosomal dominant inherited dyslipidemias, but polygenic factors contributing to susceptibility to environmental factors underlie the observed increase in LDL-C levels

After propensity score matching, the researchers identified 61,057 patients taking a GLP-1RA and an equal number taking other weight loss medications, including orlistat, phentermine-topiramate, bupropion-naltrexone or setmelanotide

In addition, estrogen is also known to activate insulin/IGF-1 (Lee et al., 2004) and PI3K/Akt (Mangan et al., 2014) pathways, potentially enhancing the mechanisms regulating MPS (Hansen et al., 2012) and consequently muscle growth (Smith et al., 2014)

This review synthesizes recent advances in understanding the mechanistic underpinnings and therapeutic potential of EA in NAFLD