does midi prescribe tirzepatide vs. Semaglutide for Weight Loss Tirzepatide | DirectMeds

doi: 10.1161/CIRCULATIONAHA.120.045691

Resting Energy Expenditure Small-scale indirect calorimetry studies suggest tirzepatide modestly increases resting energy expenditure (REE) beyond what weight loss alone predicts, an effect not consistently seen with liraglutide or semaglutide at approved doses

The combination could produce additive or even synergistic improvements in these markers, which translates directly to reduced cardiovascular risk

This pharmacokinetic profile supports the medication's mechanism of action, which includes enhancing glucose-dependent insulin secretion, suppressing inappropriate glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways