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31330-038) in a 1:1 ratio, supplemented with 5% fetal calf serum (PAA Laboratories, cat
Effective interventions are becoming more and more essential as rates of obesity among children rise
KEAP1/NRF2 mutant cells are protected against cysteine-starvation induced ferroptosis due to elevated GCLC expression and limited glutamate accumulation, and dual targeting of cystine import and GCLC activity can overcome the resistance of NRF2 active cells to ferroptosis (Kang et al., Cell Metab 2021)
Glutathione synthesis occurs in two ATP-dependent steps catalyzed by the enzymes gamma-glutamylcysteine ligase (GCL, the rate-limiting step) and glutathione synthetase [2]
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