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Recent studies have revealed that anlotinib downregulates transferrin receptor ( TFRC ) expression via the VEGFR2/AKT/HIF-1 signaling axis, thereby enhancing infiltration of immune cells such as CD8 + T lymphocytes into hepatocellular carcinoma tissue, ameliorating hypoxia, and reversing immunosuppression (27)

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Certain Cancers: Blood cancers, such as leukaemia, may increase B12 levels in the blood 4 , 11

Many key questions remain unsolved, such as the role of inflammation in the development of aortic dissection, how ferroptosis and inflammation work synergistically to promote aortic dissection, and the cause or effect relationship between ferroptosis and aortic dissection