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Sermorelin stimulation preserves negative feedback loops mediated by IGF-1, somatostatin, and other factors, creating a self-limiting system that helps prevent excessive GH production and associated risks like acromegaly-like symptoms, severe insulin resistance, or fluid retention

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Discovered in the 1970s, DSIP is found in cerebrospinal fluid (CSF) in the brain and plasma, and its key role lies in modulating sleep patterns