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Moreover, IGF-1 stimulates androgen receptor signaling by increasing adrenal and gonadal androgen synthesis as well as androgen receptor transactivation by nuclear extrusion of the androgen receptor cosuppressor FoxO1 [17, 18]

Researchers who treat GLP-3(Reta) as better GLP-1 are likely mismatching compound to research question and researchers who stay with GLP-1(Sema) when their protocol actually requires GIPR data are leaving mechanism information on the table