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Metabolic products such as nitric oxide and carbon monoxide have also been reported to act like neurotransmitters

This means that your body cannot produce it on its own, so you need to get it from outside sources

Although numerous anti-depressive treatments are available, 30% of patients diagnosed with depression do not experience positive therapeutic effects with these therapies ( The gut is a key member of the gut-brain axis owing to its own enteric nervous system and its independent responses to the exterior environment and stress (Rao and Gershon, 2016)

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