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As we age, NAD+ levels naturally decline, which has been linked to fatigue, cognitive decline, and metabolic issues

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IGF-1 LR3 and CJC-1295 both ultimately converge on skeletal muscle anabolism, yet their pharmacological mechanisms are fundamentally different: IGF-1 LR3 acts as a direct, long-acting IGF-1 receptor agonist that bypasses the hypothalamic-pituitary axis entirely, while CJC-1295 is a GHRH analogue that stimulates endogenous GH pulses from the pituitary, which then drives hepatic IGF-1 synthesis over hours

One of the most persistent was Georg Ludwig Zuelzer (figure 4), a German physician who was the Head of Internal Medicine at Hasenheide Hospital in Berlin