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Often, these individuals possess dysfunctional mutations in one or more enzymes related to glutathione function

While glutathione has antioxidant properties, cosmetic skin-lightening results vary between individuals and are not guaranteed by current clinical evidence

TX: Writing review and editing

However, KEAP1 regulates multiple pathways beyond NRF2 60,82 , and the contributions of NRF2 to lipid homeostasis have been reported to be pleiotropic and context-dependent 83