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Lifestyle intervention in childhood obesity: Changes and challenges

The hydrophilic nature and large molecular weight of these molecules prevent passive diffusion across enterocytes, and paracellular transport is restricted by TJ complexes, which typically exclude molecules larger than 1 nm or 600 Da (Shen et al., 2011

This shift is not just about the numbersits changing how physicians and patients think about managing T2D and its many related comorbidities

Diabetes 67(Supplement 1):522 Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P et al (2019) Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial