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Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)

While we dont know for sure if this GLP-1 patent lapse was a deliberate decision from Novo or a mistake, the case does shed light on the complexity of dealing with multiple jurisdictions

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Mol Cell 38:576589 Holdorf AD, Higgins DP, Hart AC, Boag PR, Pazour GJ, Walhout AJM, Walker AK (2020) WormCat: an online tool for annotation and visualization of Caenorhabditis elegans genome-scale data