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All MD simulations were performed with the program package GROMACS (version 2020.4) 32 using the GROMOS 54a7 force field 33

GLP-1 receptor agonists are intended for adults with obesity (BMI 30) or those who are overweight (BMI 27) with associated metabolic conditions such as hypertension, dyslipidaemia, or type 2 diabetes

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l Clinical observation and some preliminary studies suggest the GLP-1 medication semaglutidebetter known by brand names like Ozempic, Mounjaro, and Wegovycan reduce cravings and help individuals with alcohol use disorder reduce or stop drinking